actor gaspard ulliel

Tue, 05 May 2026 16:35:17 +0000

CD33 was identified as an AD risk gene 15 years ago (Oct 2008 news). Also known as Siglec-3, the transmembrane protein binds sialic acid and regulates innate immunity through its. CD33, a transmembrane receptor of the innate immune system, is expressed on the surface of microglial cells. Genome-wide association studies (GWAS) have linked variants in CD33 to Alzheimers disease. CD33 is a transmembrane receptor of the innate immune system that is expressed on the surface of peripheral monocytes and microglial cells in the brain. CD33 was first implicated in Alzheimers disease. The microglial receptor CD33 opposes the effects of TREM2 signaling, and may make a more amenable target because it would be inhibited rather than activated (see Part 5 of this series).